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Lab Events and News

New Paper

4/29/2024

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In our new paper, we show that a novel ribonucleoprotein complex, involving SNA-3, SUT-1 and SmY RNAs, plays a key role in nematode spliced leader trans-splicing. 

Eijlers P, Al-khafaji M, Soto-Martin E, Fasimoye, R, Stead D, Wenzel, M, Müller, B and Pettitt J. (2024). A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs. Nucleic Acids Res.
​https://doi.org/10.1093/nar/gkae321
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Long overdue update!

4/9/2024

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New Lab Members

We were pleased to welcome two new lab members, who started in October 2022 (see, it is a long overdue update) - Eileen Clemens and Maheshika Kurukulasuriya, both of whom are PhD students funded by BBSRC EASTBIO DTP studentships. Maheshika's studentship is a CASE award, in collaboration with BioAscent Discovery Ltd. 

Rosie Graduates

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Rosie graduated in June 2023, after successfully defending her thesis, SNA-3 and SUT-1: critical
components involved in nematode
spliced leader trans-splicing
​, in November 2022.
We still miss her!

​
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New paper

6/24/2022

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AlphaFold prediction for SNA-3. The NADAR (NAD and ADP-Ribose) domains, two of which we show are essential for its function, are coloured purple, hot pink and cyan.
We are pleased to announce a new paper

Fasimoye RY, Spencer REB, Soto-Martin E, Eijlers P, Elmassoudi H, Brivio S, et al. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Nucleic Acids Res. (in press).
academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac534/6613924

​
We will be updating the research page to give an account of this work shortly, but for now there is a twitter thread about it here
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New PhD Student

11/12/2020

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We are happy to welcome Mohammed Al-Khafaji to the lab. Mohammed will be working on identifying the key RNA-protein interactions that target SL2 RNAs to mRNAs derived from downstream genes in operons.
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New lab members

10/22/2020

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Two new lab members started this month - Sarah Brivio and Viktorija Sabele, who are doing their Masters by Research in the lab. 
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New Paper Accepted

9/9/2020

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Marius Wenzel, Christopher Johnston, Berndt Müller, Jonathan Pettitt, and Bernadette Connolly.  (2020). Resolution of polycistronic RNA by SL2 trans-splicing is a widely-conserved nematode trait. RNA doi: 10.1261/rna.076414.120

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New lab members

3/3/2020

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In February we welcomed three new lab members: Dr Eva Soto; Peter Eijlers and Fayisola Fasimoye. 
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Ara Passes Her PhD Viva

12/17/2019

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Ara successfully defends her thesis: "Assembling an orthogonal translation compartment in S. cerevisiae". Thanks to Sam Miller (far left) and Judith Sleeman (left) for examining the thesis.
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Rotimi and Haitem graduate

11/22/2019

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New research positions available

11/1/2019

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Three new research positions are available to work on two new projects in the lab.

Understanding the mechanism of a nematode Achilles’ heel.
Research Technician - 3 year position, funded by the BBSRC - application deadline: 08/11/19.
Postdoctoral Research Fellow - 3 year position, funded by the BBSRC - application deadline: 08/11/19.

Recurrent evolution of a eukaryotic molecular trait: acquisition of polycistronic RNA processing.
PhD Studentship - 4 year, funded by EASTBIO BBSRC.
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