 In our new paper, we show that a novel ribonucleoprotein complex, involving SNA-3, SUT-1 and SmY RNAs, plays a key role in nematode spliced leader trans-splicing.
Eijlers P, Al-khafaji M, Soto-Martin E, Fasimoye, R, Stead D, Wenzel, M, Müller, B and Pettitt J. (2024). A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs. Nucleic Acids Res. https://doi.org/10.1093/nar/gkae321
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New Lab MembersWe were pleased to welcome two new lab members, who started in October 2022 (see, it is a long overdue update) - Eileen Clemens and Maheshika Kurukulasuriya, both of whom are PhD students funded by BBSRC EASTBIO DTP studentships. Maheshika's studentship is a CASE award, in collaboration with BioAscent Discovery Ltd. Rosie Graduates
We are happy to welcome Mohammed Al-Khafaji to the lab. Mohammed will be working on identifying the key RNA-protein interactions that target SL2 RNAs to mRNAs derived from downstream genes in operons.
Two new lab members started this month - Sarah Brivio and Viktorija Sabele, who are doing their Masters by Research in the lab.
Marius Wenzel, Christopher Johnston, Berndt Müller, Jonathan Pettitt, and Bernadette Connolly. (2020). Resolution of polycistronic RNA by SL2 trans-splicing is a widely-conserved nematode trait. RNA doi: 10.1261/rna.076414.120
In February we welcomed three new lab members: Dr Eva Soto; Peter Eijlers and Fayisola Fasimoye.
 Ara successfully defends her thesis: "Assembling an orthogonal translation compartment in S. cerevisiae". Thanks to Sam Miller (far left) and Judith Sleeman (left) for examining the thesis. Three new research positions are available to work on two new projects in the lab.
Understanding the mechanism of a nematode Achilles’ heel. Research Technician - 3 year position, funded by the BBSRC - application deadline: 08/11/19. Postdoctoral Research Fellow - 3 year position, funded by the BBSRC - application deadline: 08/11/19. Recurrent evolution of a eukaryotic molecular trait: acquisition of polycistronic RNA processing. PhD Studentship - 4 year, funded by EASTBIO BBSRC. |
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